Is CAD genetic?

The past decade of research has provided a broader understanding of the genetic architecture of CAD and demonstrates that the genetic basis of CAD largely derives from the cumulative effect of multiple common risk alleles individually of small effect size rather than rare variants with large effects on CAD risk.

How has technology changed the genetics of CAD & other complex diseases?

Recent progress in understanding the genetics of CAD and other complex diseases has been driven by technological advances, including high-throughput DNA microarray technology using chips containing up to a million DNA markers consisting of single-nucleotide polymorphisms (SNPs).

How does CAD differ from monogenic disorders?

Unlike monogenic disorders, in which a single genetic variant can be a definitive marker for the diagnosis, CAD is mainly developed by the accumulation of many common variants with weak effects and high frequency.

Are CAD and FES genes related?

Finally, in the locus #44, all in silico studies prioritized both FURIN and FES genes. Our SMR/HEIDI analysis found association between CAD and FURIN expression changes in blood, and between CAD and FES expression changes in blood and CD14 + and CD19 + cells.